Medicine
Tirzepatide: what to keep track of day to day
Quick answer
Tirzepatide is taken once a week and has a half-life of about 5 days. It acts on two receptors, GIP and GLP-1. In the U.S. it comes as Mounjaro® and Zepbound®.
What to know
- Half-life of about 5 days; levels peak 8 to 72 hours after a shot.
- Side effects listed most often on the label: nausea, diarrhea, decreased appetite, vomiting and constipation.
- The label notes that tirzepatide can make birth control pills less effective for a few weeks after you start and after each dose increase. If you take the pill, ask your doctor about a backup method.
- Keeping an eye on protein and strength training is a simple way to look after your muscle.
Tools and guides
Protein · Water · Fiber · Nausea · Constipation
Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. Leve is independent and not affiliated with Eli Lilly; brand names appear only to help you identify your treatment.
Limits
- Your dose and any dose change are decided by your doctor.
- Compounded tirzepatide is not FDA-approved: check where it comes from with your doctor and pharmacist.
- This page is for information only. It doesn't replace the prescribing information or your doctor.
Sources
- FDA prescribing information for Mounjaro® and Zepbound® (tirzepatide).
- FDA: concerns with unapproved GLP-1 drugs used for weight loss.
Reviewed on November 7, 2026. General information, pending review by a health professional. Leve doesn't replace your doctor's advice.
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